Neurodevelopmental Effects of Fetal Antiepileptic Drug Exposure
نویسندگان
چکیده
منابع مشابه
Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years.
OBJECTIVE To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure. METHODS The NEAD Study is an ongoing prospective observational multicenter study, which enrolled pregnant women with epilepsy on AED monotherapy (1999-2004) to determine if differential long-term neurodevelopmental effects exist across 4 commonly used AEDs (carb...
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In the immature brain, ethanol impairs insulin, insulin-like growth factor (IGF) and other trophic factor signaling, increases cellular stress, and impairs neuronal and glial functions. However, given the phenotypic heterogeneity of fetal alcohol spectrum disorder (FASD), which is not always ethanol dose-dependent, we hypothesized that cofactors modulate spectrum and severity of disease. Herein...
متن کاملAdverse Metabolic Effects of Antiepileptic Drug Treatment
Active epilepsy with recurrent seizures is associated with a range of well-documented unfavourable consequences. Nevertheless, adverse metabolic effects of antiepileptic drug (AED) treatments have only recently received attention. Such effects may be subtle, insidious, take many years to become clinically apparent, and may have a negative impact on general health for many decades. Unfortunately...
متن کاملSensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort
INTRODUCTION Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data on neurodevelopmental outcomes and its comparability with data generated through other methodologies is unknown. OBJECTIVES The objectives of this study were to determine whether data from the UK Clinical Practice Research Datalink (CPRD) produces similar risk es...
متن کاملCurrent Review in Clinical Science Effects of in Utero Antiepileptic Drug Exposure
Recent studies demonstrate an increased teratogenic risk for valproate and a probable increased risk for phenobarbital. Carbamazepine and lamotrigine appear relatively safe; however, results are inconclusive concerning a specific risk for cleft lip/palate for both drugs as well as a dose-dependent effect for malformations associated with lamotrigine. Data regarding teratogenic risks for other a...
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ژورنال
عنوان ژورنال: Drug Safety
سال: 2015
ISSN: 0114-5916,1179-1942
DOI: 10.1007/s40264-015-0269-9